An Indirect Microhemagglutination Test for Lyme Disease

• FUJITA Hiromi

  The Laboratory of Ohara General Hospital

• SATO Tadashi

  The Laboratory of Ohara General Hospital

• OHARA Yoshiro

  Department of Neurological Sciences, Tohoku University School of Medicine

• HOMMA Morio

  Department of Microbiology, Kobe University School of Medicine

抄録

We have developed an indirect microhemagglutination test (IMHA) for detecting antibodies to Borrelia burgdorferi using formalin-fixed chicken erythrocytes sensitized with a sonicated extract of the bacteria. The specificity of IMHA for Lyme disease was compared with that of a conventional indirect immunoperoxidase technique (IP) using sera from the patients with syphilis, randomly-chosen outpatients unrelated to Lyme disease, and from normal individuals. The IMHA was more specific than IP, giving little cross-reaction with syphilis. The IMHA also gave little background reactions with the sera of individuals unrelated to Lyme disease or syphilis. Therefore, the IMHA could be a useful test for the serodiagnosis of Lyme disease.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 35 (7), 589-592, 1991

  Center For Academic Publications Japan

詳細情報

• CRID: 1573668927871394688
• NII論文ID: 130003483798
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00077813619?from=CiNii
• 本文言語コード: en
• データソース種別:
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