Comparison of Secretory Acid Proteinases from <i>Candida tropicalis, C. parapsilosis</i> and <i>C. albicans</i>

• SONO Eiko

  Biotechnology Research Laboratories, Takara Shuzo Co., Ltd.

• MASUDA Tomoko

  Biotechnology Research Laboratories, Takara Shuzo Co., Ltd.

• TAKESAKO Kazutoh

  Biotechnology Research Laboratories, Takara Shuzo Co., Ltd.

• KATO Ikunoshin

  Biotechnology Research Laboratories, Takara Shuzo Co., Ltd.

• UCHIDA Katsuhisa

  Research Center for Medical Mycology, Teikyo University

• MURAYAMA Somay Yamagata

  Department of Bacteriology, Teikyo University School of Medicine

• YAMAGUCHI Hideyo

  Research Center for Medical Mycology, Teikyo University

抄録

Acid proteinases secreted by Candida tropicalis and C. parapsilosis were newly isolated. Their physico-chemical and enzymatic properties of molecular weight, pH stability, isoelectric points, specific activity, and N-terminal amino acid sequences were determined and compared with those of a C. albicans acid proteinase. The two acid proteinases secreted by C. parapsilosis were found to be new enzymes in their molecular weights. The acid proteinases from C. tropicalis and C. parapsilosis showed lower activity at neutral pH, less resistance to neutral and alkaline pH than that from C. albicans, and a half or a third of the specific activity of the C. albicans enzyme. These differences seemed to be associated with the difference of pathogenesis between Candida species. Of the 31 N-terminal amino acids, the enzymes of these three Candida species revealed 12 homologous amino acids.

収録刊行物

• MICROBIOLOGY and IMMUNOLOGY

  MICROBIOLOGY and IMMUNOLOGY 36 (10), 1099-1104, 1992

  Center For Academic Publications Japan

詳細情報

• CRID: 1573387452894620544
• NII論文ID: 130003483831
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00079052054?from=CiNii
• 本文言語コード: en
• データソース種別:
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