A Factor Found in Aged Tungstate Solution Enhanced the Antibacterial Effect of β-Lactams on Methicillin-Resistant <i>Staphylococcus aureus</i>
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- Tajima Yutaka
- Clinical Laboratory, Saga Medical School Hospital
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- Nagasawa Zenzo
- Clinical Laboratory, Saga Medical School Hospital
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- Tadano Jutaro
- Clinical Laboratory, Saga Medical School Hospital
抄録
We have found a factor (Factor T) in aged mixtures of tungstate and phosphate which greatly enhances the antibacterial effects of β-lactams on both inducible and constitutive methicillin-resistant Staphylococcus aureus, but not on methicillin-susceptible S. aureus. Factor T alone did not strongly inhibit bacterial growth. There was no synergism of Factor T with other classes of antibiotics, nor with other groups of bacteria, and it reduced the efficacy of amino-glycosides and tetracycline. Upon preparation of Factor T, acidifying and heating the mixture of tungstate and phosphate resulted in a high yield and reproducibility, and no enhancing effect was observed when other anions such as sulfate or molybdate were used instead. Factor T is heat- and acid-stable but labile to alkalization, and is probably a complex of phosphate and tungstate.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 37 (9), 695-703, 1993
Center For Academic Publications Japan
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詳細情報 詳細情報について
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- CRID
- 1571698603035477120
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- NII論文ID
- 130003484007
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- ISSN
- 03855600
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles