<i>Helicobacter pylori</i> Induces Inflammation in Mouse Urinary Bladder and Pelvis

J-STAGE
  • Isogai Hiroshi
    Division of Animal Experimentation, School of Medicine, Sapporo Medical University
  • Isogai Emiko
    Department of Preventive Dentistry, School of Dentistry, Higashi-Nippon-Gakuen University
  • Kimura Koichi
    Department of Microbiology, School of Medicine, Sapporo Medical University
  • Fujii Nobuhiro
    Department of Microbiology, School of Medicine, Sapporo Medical University
  • Yokota Kenji
    Department of Microbiology, Faculty of Medicine, Okayama University
  • Oguma Keiji
    Department of Microbiology, Faculty of Medicine, Okayama University

抄録

Helicobacter pylori was transurethrally inoculated into the mouse urinary tract. The organism established infection and induced inflammation in the urinary bladder and pelvis. During the infection, urinary pH was elevated, probably due to the production of NH3 by bacterial urease. H. pylori was recovered from the urinary bladder, kidney and urine of the infected mice. Histopathologically, severe neutrophil infiltration was observed in the mucosal layer of both organs. H. pylori was detected on the surface of the epithelial cells. These results indicate that low pH and bacterial flora were not essential factors in establishing the mucosal infection with H. pylori. This experimental system is useful to investigate the pathogenicity of H. pylori in mucosal organs.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ