Genotype Analysis of Hepatitis C Virus among Blood Donors and Inmates in Metro Manila, The Philippines

J-STAGE
  • Katayama Yuko
    Department of Microbiology, Kobe University School of Medicine
  • Barzaga Nina G.
    Department of Medical Microbiology, College of Public Health, University of The Philippines Manila
  • Alipio Arlene
    Department of Medical Microbiology, College of Public Health, University of The Philippines Manila
  • Soetjipto
    Tropical Disease Research Center, Airlangga University
  • Doi Hisaya
    Department of Microbiology, Kobe University School of Medicine
  • Ishido Satoshi
    Department of Microbiology, Kobe University School of Medicine
  • Hotta Hak
    Department of Microbiology, Kobe University School of Medicine

抄録

Antibodies against hepatitis C virus (HCV) were detected in 18 (2.3%) of 800 sera from commercial blood donors and 23 (4.6%) of 502 sera from inmates in Metro Manila, the Philippines. The difference in the antibody prevalence between the two groups was statistically significant (P<0.05). HCV RNA was detected in 14 (78%) of the 18 antibody-positive sera from blood donors and 19 (83%) of the 23 antibody-positive sera from inmates. Genotype analysis revealed that HCV-1b (50%) was most common among blood donors, followed by HCV-1a (36%) and HCV-2a (7%). Among inmates, on the other hand, HCV-1a (68%) was most common, followed by HCV-1b (11%), HCV-2a (5%) and HCV-2b (5%). Overall, HCV-1a and HCV-1b appeared to be predominant among them. Thus, the genotype prevalence in the Philippines was distinct from those in other Southeast Asian countries such as Thailand, Vietnam and Indonesia, and also distinct from those in the Far East including Taiwan, Mainland China and Japan.

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