Production of a T-Cell Clone Which Reacts with Membrane Proteins of <i>Acholeplasma laidlawii</i>

• Kuwano Koichi

  Department of Microbiology, Kurume University School of Medicine

• Ono Saori

  Department of Microbiology, Kurume University School of Medicine

• Akashi Akira

  Department of Microbiology, Kurume University School of Medicine

• Ohishi Masahiro

  Department of Microbiology, Kurume University School of Medicine

• Shigematsu Hideki

  Department of Microbiology, Kurume University School of Medicine

• Arai Sumio

  Department of Microbiology, Kurume University School of Medicine

Abstract

The role of cellular immunity in mycoplasma infection is not completely understood. In this study, we established mycoplasma-specific T-cell clones to evaluate cellular immunity in mycoplasma infection. We developed a T-cell clone (G-10) which was stimulated with Acholeplasma laidlawii. The T-cell clone G-10, CD4⁺ and T-cell receptor (TCR) αβ⁺ recognized the 42- and 65-kilodalton (kDa) membrane proteins of A. laidlawii and responded to A. hippikon. Hence, the application of mycoplasma-specific T cells such as G-10 in animal models may allow the assessment of cellular immune response to mycoplasma infection.

Journal

• Japanese Journal of Microbiology

  Japanese Journal of Microbiology 41 (3), 261-264, 1997

  Center For Academic Publications Japan

Details

• CRID: 1572543027965313664
• NII Article ID: 130003484496
• ISSN: 03855600
• Web Site: https://jlc.jst.go.jp/DN/JALC/00083591884?from=CiNii
• Text Lang: en
• Data Source:
  • CiNii Articles