Isolation of a New <i>Orientia tsutsugamushi</i> Serotype

J-STAGE
  • Seong Seung-Yong
    Department of Microbiology, Seoul National University College of Medicine
  • Park Sae-Gwang
    Department of Microbiology, Seoul National University College of Medicine
  • Kim Hang-Rae
    Department of Microbiology, Seoul National University College of Medicine
  • Han Tae-Hee
    Department of Microbiology, Seoul National University College of Medicine
  • Kang Jae-Seung
    Department of Microbiology, Inha University College of Medicine
  • Choi Myung-Sik
    Department of Microbiology, Seoul National University College of Medicine
  • Kim Ik-Sang
    Department of Microbiology, Seoul National University College of Medicine
  • Chang Woo-Hyun
    Department of Microbiology, Hallym University College of Medicine

抄録

Orientia tsutsugamushi, the etiological agent of scrub typhus, is an antigenically diverse organism and many serologically distinct strains have been identified. The 56kDa protein of O. tsutsugamushi, a major protein in the outer membrane, has been thought to be responsible for this antigenic variability. A strain of O. tsutsugamushi isolated in Korea cross-reacted with both Gilliam strain-specific and Karp strain-specific monoclonal antibodies. When its 56kDa protein gene was cloned and analyzed, its sequence showed variation especially between 1, 200 and 1, 250bp, showing that this isolate is a new O. tsutsugamushi strain.

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