<i>Moraxella (Branhamella) catarrhalis</i> Adherence to Human Bronchial and Oropharyngeal Cells: The Role of Adherence in Lower Respiratory Tract Infections
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- Rikitomi Naoto
- Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
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- Ahmed Kamruddin
- Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
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- Nagatake Tsuyoshi
- Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
書誌事項
- タイトル別名
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- <i>Moraxella (Branhamella) catarrhalis</i> Adherence to Human Bronchial and Oropharyngeal Cells
抄録
To study the role of Moraxella (subgenus Branhamella) catarrhalis (B. catarrhalis) adherence to airway cells in lower respiratory tract infections, the in vitro attachments of B. catarrhalis to upper airway (oropharyngeal) and lower airway (bronchial) epithelial cells were compared. The adherence of 4 strains (1 nonfimbriated and 3 fimbriated) of B. catarrhalis to respiratory tract epithelial cells collected from 11 patients with chronic pulmonary disease (CPD) and 11 healthy individuals was evaluated. Both the fimbriated and nonfimbriated strains showed increased attachment to oropharyngeal cells in the CPD patients (mean±SEM; 25.0±3.2/cell; P<0.01) when compared to the control subjects (12.1±1.1/cell). On the average, the attachment to bronchial cells was 6.1 to 13.6 times greater per surface area (bacteria/μm2) than the attachment to oropharyngeal cells. The fimbriated strains tended to adhere in higher numbers to bronchial cells (19.0±1.8/cell) than the nonfimbriated strain (8.7±1.2/cell), although there was no difference between the CPD and control groups. In conclusion, the attachment of B. catarrhalis to oropharyngeal cells may be an enhancing factor for colonization in the upper respiratory tract in patients with CPD, and elevated adherence of the bacteria to bronchial cells may suggest pathogenic importance when mucociliary function is impaired.
収録刊行物
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 41 (6), 487-494, 1997
財団法人 学会誌刊行センター
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詳細情報
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- CRID
- 1390282681295124608
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- NII論文ID
- 130003484528
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- COI
- 1:CAS:528:DyaK2sXkvVaktrs%3D
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- ISSN
- 13480421
- 03855600
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- PubMed
- 9251060
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可