Protection Induced in Mice Vaccinated with Recombinant Collagen-Binding Protein (CnBP) and Alpha-Toxoid against Intramammary Infection with <i>Staphylococcus aureus</i>

J-STAGE
  • Mama Wubshet
    Section of Bacteriology and Epizootology, Department of Veterinary Microbiology, Swedish University of Agricultural Sciences
  • Fröman Gunnar
    Department of Medical Biochemistry & Microbiology, Unit of Microbiology, University of Uppsala
  • Müller Hans-Peter
    Department of Microbiology, Swedish University of Agricultural Sciences

抄録

Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (α-toxoid) were significantly protected from intramammary challenge infection with S. aureus. The average number of bacteria recovered from the glands of mice vaccinated with the combination of CnBP/α-toxoid was significantly lower compared to the average number of bacteria recovered from the glands of mice vaccinated with only CnBP or α-toxoid or controls (P≤0.01). Histopathological examination of mammary glands of mice vaccinated with CnBP together with α-toxoid showed no pathological changes, whereas glands of mice vaccinated with CnBP or α-toxoid alone developed severe mastitis and showed both focal and disseminated necrosis.

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