Effects of flavine adenine dinucleotide on the platelet aggregation induced by collagen or ADP.

Access this Article



It was revealed in the present study that flavine adenine dinucleotide (FAD) could inhibit both collagen- and ADP-induced aggregation of human platelets in vitro at the final concentrations of micromolar level. Also flavine mononucleotide and riboflavin showed a moderate degree of inhibition on the ADP-induced platelet aggregation. FAD may enhance further the inhibition of platelet aggregation by aspirin, suggesting different mechanism. The possible mechanism under-lying the inhibition of platelet aggregation in vitro by FAD and related sub-stances was discussed. Also, a preliminary study has suggested that the inhibitory effect of FAD on the platelet aggregation was observable not only in vitro, but also in vivo. The intravenous administration of a relatively high dose of FAD to a few patients with various diseases was followed by a slight and transient decrease of the collagen-induced platelet aggregation.


  • The Tohoku Journal of Experimental Medicine

    The Tohoku Journal of Experimental Medicine 130(3), 219-226, 1980

    Tohoku University Medical Press


  • NII Article ID (NAID)
  • Text Lang
  • ISSN
  • Data Source
Page Top