Effects of flavine adenine dinucleotide on the platelet aggregation induced by collagen or ADP.
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It was revealed in the present study that flavine adenine dinucleotide (FAD) could inhibit both collagen- and ADP-induced aggregation of human platelets in vitro at the final concentrations of micromolar level. Also flavine mononucleotide and riboflavin showed a moderate degree of inhibition on the ADP-induced platelet aggregation. FAD may enhance further the inhibition of platelet aggregation by aspirin, suggesting different mechanism. The possible mechanism under-lying the inhibition of platelet aggregation in vitro by FAD and related sub-stances was discussed. Also, a preliminary study has suggested that the inhibitory effect of FAD on the platelet aggregation was observable not only in vitro, but also in vivo. The intravenous administration of a relatively high dose of FAD to a few patients with various diseases was followed by a slight and transient decrease of the collagen-induced platelet aggregation.
- The Tohoku Journal of Experimental Medicine
The Tohoku Journal of Experimental Medicine 130(3), 219-226, 1980
Tohoku University Medical Press