A rat model for monitoring homograft rejection of the lung.

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  • KONDO TAKASHI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • SHIONOZAKI FUMIHIRO
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • FUJIMURA SHIGEFUMI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • YAMAUCHI ATSUSHI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • HANDA MASASHI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • OKABE TAKESHI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • SAITO RYO
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • ICHINOSE TAKASHI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • SHIRAISHI YUJI
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University
  • NAKADA TASUKU
    Department of Surgery, the Research Institute for Tuberculosis and Cancer, Tohoku University

Abstract

KONDO, T., SHIONOZAKI, F., FUJIMURA, S., YAMAUCHI, A., HANDA, M., OKABE, T., SAITO, R., ICHINOSE, T., SHIRAISHI, Y. and NAKADA, T. A Rat Model for Monitoring Homograft Rejection of the Lung. Tohoku J. exp. Med., 1986, 149 (3), 323-328 - A new surgical procedure was devised for the experimental homograft of the lung. The pulmonary artery and vein and bronchus were anastomosed under the operation microscope using interrupted sutures in group W (30 outbred Wistar rats) and continuous sutures in group F (7 inbred F344/Ducrj Rats). Mean ischemia time during the operation was 95.3±10.3min in the group W and 55.6± 5.8 in group F. Eight out of 30 rats (27%) of group W and all rats of group F survived more than 24hr after the surgery. Pulmonary functions of grafted lungs were evaluated by serial x-rays and the perfusion ratio was 27.4±11.6% (mean± S.D.) in group W and 25.4±7.7% in group F. A patent opening of the hilar anastomosis in these rats was confirmed at autopsy. This model with continuous suture would be useful for the rat lung transplantation.

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