Experimental Studies of the Effect of Calcium Deficient Diet on the Development of Cerebrovascular Diseases

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Abstract

A long-period experimental study on the effect of the diets of different calcium content was conducted using 136 albino rats of Wistar strain for 24 morAbs. Differentiation of mortality and mean body weight among those groups was marked at the first twelve months compared to the second. Balance study between in-take and output, and also quantitative analysis of minerals in tissue and organ speci-mens revealed that the adaptation for the low calcium diet was accomplished by the later stage of life, and the analytical values between groups stayed within individual variation. However histopathological investigation revealed that the specific changes attributable to the low calcium diet appeared as local-ized fibrotic foci scattered in ventricular wall and scattered softening foci of status spongiosus accompanied with glia cell swellings in diencephalon after long-period feeding with the calcium deficient diet.

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