Kalafungin,a new broad spectrum antibiotic isolation and characterization

• BERGY M. E.

  Research Laboratories, The Upjohn Company

書誌事項

タイトル別名

• KALAFUNGIN, A NEW BROAD SPECTRUM ANTIBIOTIC
• ISOLATION AND CHARACTERIZATION

抄録

Kalafungin is a new antibiotic extracted from the fermentation broth of Streptomyces tanashiensis strain Kala, and purified by chromatography on silica gel followed by crystallization. It is a weakly acidic, orange colored compound, pKa=10.0, with a molecular formula C₁₆H₁₂O₆ and a molecular weight of 300. It is dextrorotatory in chloroform, [α]²⁵_D+159, and exhibits ultraviolet and visible absorption maxima at 212, 256, and 425 mμ in methanol.<br> Kalafungin melts at 163-166°C and is readily soluble in ethyl acetate, chloroform, and acetone but only slightly soluble in water.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 21 (7), 454-457, 1968

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679128910592
• NII論文ID: 130003498109
• NII論文ID: 10008469835
• NII論文ID: 40018688278
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.21.454
• COI: 1:CAS:528:DyaF1MXit1yltA%3D%3D
• ISSN: 18811469
• ISSN: 00218820
• NDL書誌ID: 8509934
• PubMed: 4303501
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8509934
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可