UDP-N-methyl-D-glucosamine-phosphate - a possible intermediate of N-methyl-L-glucosamine moiety of streptomycin.
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The formation of <i>N</i>-methyl-L-glucosamine moiety of streptomycin from n-glucosamine by <i>Streptomyces griseus</i> was studied. The addition of thymine to the culture medium stimulated the formation of streptomycin and the incorporation of D-glucosamine into <i>N</i>-methyl-L-glucosamine moiety. During a study of sugar nucleotides in the mycelia, a novel UDP-amino sugar was isolated. The compound was formed before the maximum production of streptomycin. It was UDP-<i>N</i>-methyl-n-glucosamine-phosphate.
- The Journal of Antibiotics
The Journal of Antibiotics 35(11), 1571-1577, 1982
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION