Deacetylravidomycin N-oxide, a new antibiotic. Taxonomy and fermentation of the producing organism and isolation, structure and biological properties of the antibiotic.
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- NARITA TADASHI
- Central Research Laboratories, SS Pharmaceutical Co.
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- MATSUMOTO MASARU
- Central Research Laboratories, SS Pharmaceutical Co.
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- MOGI KINICHI
- Central Research Laboratories, SS Pharmaceutical Co.
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- KUKITA KEN-ICHI
- Central Research Laboratories, SS Pharmaceutical Co.
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- KAWAHARA RYUICHI
- Central Research Laboratories, SS Pharmaceutical Co.
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- NAKASHIMA TOSHIAKI
- Central Research Laboratories, SS Pharmaceutical Co.
抄録
Streptomyces ravidus S50905 was found to produce a new antibiotic, deacetylravidomycin N-oxide, together with ravidomycin and deacetylravidomycin in a culture medium containing sodium anthraquinone-β-sulfonate. The structure of this new compound was determined from NMR and mass spectrometric data, and further confirmed by chemical synthesis from deacetylravidomycin.<br> Deacetylravidomycin N-oxide was antitumor active against P388 leukemia and Meth A fibrosarcoma in a wide range of doses, and considerably less toxic than deacetylravidomycin. Its antibacterial activity was less potent than deacetylravidomycin. Ravidomycin N-oxide was also synthesized from ravidomycin and its biological properties were tested.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 42 (3), 347-356, 1989
公益財団法人 日本感染症医薬品協会
