New cyclodepsipeptides, enniatins D, E and F produced by Fusarium sp. FO-1305.
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New cyclodepsipeptides named enniatins D, E and F were isolated from the culture broth of <i>Fusarium</i> sp. FO-1305 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). The respective structures of enniatins D, E and F were determined to be cyclo[D-α-hydroxyisovaleryl(D-Hiv)-L-<i>N</i>-methylleucinyl (L-Me-Leu)-D-Hiv-L-<i>N</i>-methylvalinyl(L-Me-Val)-D-Hiv-L-Me-Val], a mixture of cyclo[D-Hiv-L-Me-Leu-D-Hiv-L-<i>N</i>-methylisoleuciny (L-Me-He-D)-D-Hiv-L-Me-Val], and cyclo(D-Hiv-L-Me-Ile-D-Hiv-L-Me-Leu-o-Hiv-L-Me-Val), and cyclo (D-Hiv-L-Me-Leu-D-Hiv-L-Me-Ile-D-Hiv-L-Me-Ile) by spectral analyses and chemical degradation. The IC<sub>50</sub> values of enniatins D, E and F for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 87, 57 and 40μM, respectively.
- The Journal of Antibiotics
The Journal of Antibiotics 45(8), 1207-1215, 1992
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION