Enzymatic dimerization of penicillin X.

• AGEMATU HITOSI

  Central Research Laboratories, Mercian Co.

• TSUCHIDA Tosmo

  Central Research Laboratories, Mercian Co.

• KOMINATO KAICHIRO

  Central Research Laboratories, Mercian Co.

• SHIBAMOTO NORIO

  Central Research Laboratories, Mercian Co.

• YOSHIOKA TAKEO

  Central Research Laboratories, Mercian Co.

• NISHIDA HIROSHI

  Central Research Laboratories, Mercian Co.

• OKAMOTO ROKURO

  Central Research Laboratories, Mercian Co.

• SHIN TAKASHI

  Department of Applied Microbial Technology

• MURAO SAWAO

  Department of Applied Microbial Technology

Abstract

Penicillin X methyl ester was transformed into three types of dimer by laccase from Coriolus versicohr. The dimers are considered to be formed by free-radical addition of phenoxy radicals produced by laccase. The enzyme reaction with the ester as substrate was more suitable for forming dimers than that with the sodium salt as substrate. Penicillin X pivaloyloxymethyl ester was also transformed into a dimer, which had antibacterial activity in the presence of esterase.

Journal

• The Journal of Antibiotics

  The Journal of Antibiotics 46 (1), 141-148, 1993

  JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Keywords

• Drug Discovery
• Pharmacology

Details

• CRID: 1390001204149719168
• NII Article ID: 130003502401
• DOI: 10.7164/antibiotics.46.141
• COI: 1:CAS:528:DyaK3sXktVymt70%3D
• ISSN: 18811469
• ISSN: 00218820
• ISSN: http://id.crossref.org/issn/00218820
• PubMed: 8436547
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed