Effect of conagenin in tumor bearing mice. Antitumor activity, generation of effector cells and cytokine production.
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- KAWATSU MASAJI
- Institute for Chemotherapy, M.C.R.F.
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- YAMASHITA TAKASHI
- Institute for Chemotherapy, M.C.R.F.
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- OSONO MICHIYO
- Institute for Chemotherapy, M.C.R.F.
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- MASUDA TOHRU
- Institute for Chemotherapy, M.C.R.F.
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- ISHIZUKA MASAAKI
- Institute for Chemotherapy, M.C.R.F.
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- TAKEUCHI TOMIO
- Institute for Chemotherapy, M.C.R.F.
書誌事項
- タイトル別名
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- ANTITUMOR ACTIVITY, GENERATION OF EFFECTOR CELLS AND CYTOKINE PRODUCTION
抄録
Antitumor effects and function of T cells in tumor bearing mice given conagenin (CNG), a low molecular immunomodulator, were investigated. The administration of CNG, once a week for 4 weeks, was the most effective schedule in inhibiting growth of IMC carcinoma, a syngeneic tumor. In this regimen, cytotoxic T lymphocytes and natural killer activities in spleens of CNG treated mice were maintained at higher levels than those of non-treated mice. Lymphokine production by splenic T cells was also enhanced in cultures, whereas monokine production by macrophages, which was increased in accordance with tumor growth, was reduced by CNG administration.<br> The autitumor effect of CNG was not observed in mice given anti-asialo GM1 serum and in athymic mice.<br> Results shown in this report suggest that CNG exerts its antitumor effects through activation of T cells and enhancement of generation of antitumor effector cells.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 46 (11), 1692-1698, 1993
公益財団法人 日本感染症医薬品協会