Concanamycin B Inhibits the Expression of Newly-synthesized MHC Class II Molecules on the Cell Surface.
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- ITO KOUICHI
- Central Research Laboratories of Ajinomoto Co. Inc. Present address, Department of Inflammation and Autoimmune Diseases, Hoffmann-La Roche Inc.
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- KOBAYASHI TSUYOSHI
- Central Research Laboratories of Ajinomoto Co. Inc.
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- MORIYAMA YOSHINORI
- Department of Organic Chemistry and Biochemistry, Institute of Scientific and Industrial Research, Osaka University
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- TOSHIMA KAZUNOBU
- Department of Applied Chemistry, Faculty of Science and Technology, Keio University
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- TATSUTA KUNIAKI
- Department of Applied Chemistry, Faculty of Science and Technology, Keio University
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- KAKIUCHI TERUTAKA
- Department of Allergology, Institute of Medical Science, University of Tokyo Present address, Department of Immunology, Toho University School of Medicine
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- FUTAI MASAMITSU
- Department of Organic Chemistry and Biochemistry, Institute of Scientific and Industrial Research, Osaka University
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- PLOEGH HIDDE L.
- Center for Cancer Research, MIT
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- MIWA KIYOSHI
- Central Research Laboratories of Ajinomoto Co. Inc.
抄録
We screened natural chemical compounds which inhibit the expression of newly-synthesized MHC class II molecules on the cell surface. IFN-γ stimulates Colo 205 adenocarcinoma cells to induce the expression of MHC class I, MHC class II, and 1C AM-1 molecules on the cell surface. We show here that concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, whereas it does not affect the expression of MHC class I and ICAM-1 molecules. Concanamycin B also abrogates the enhancement of the MHC class II expression by IL-4 on mouse lymphocytes. Furthermore, concanamycin B suppresses the antigen presentation by MHC class II molecules.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 48 (6), 488-494, 1995
公益財団法人 日本感染症医薬品協会