CJ-15,801, a Novel Antibiotic from a Fungus, Seimatosporium sp.

  • SUGIE YUTAKA
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • DEKKER KOEN A.
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • HIRAI HIDEO
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • ICHIBA TOSHIO
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • ISHIGURO MASARU
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • SHIONI YUKIO
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • SUGIURA AKEMI
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
  • BRENNAN LORI
    PGRD, Groton Laboratories, Pfizer Inc.
  • DUIGNAN JOAN
    PGRD, Groton Laboratories, Pfizer Inc.
  • HUANG LIANG HSIUNG
    PGRD, Groton Laboratories, Pfizer Inc.
  • SUTCLIFFE JOYCE
    PGRD, Groton Laboratories, Pfizer Inc.
  • KOJIMA YASUHIRO
    Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.

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抄録

A novel antibiotic, CJ-15, 801 (I), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an α, β-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50μml

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 54 (12), 1060-1065, 2001

    公益財団法人 日本感染症医薬品協会

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