Stachyflin and Acetylstachyflin, Novel Anti-influenza A Virus Substances, Produced by Stachybotrys sp. RF-7260. I. Isolation, Structure Elucidation and Biological Activities.
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- MINAGAWA KAZUYUKI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- KOUZUKI SHUICHI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- YOSHIMOTO JUN
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- KAWAMURA YOSHIMI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- TANI HIROYOSHI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- IWATA TATSUO
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- TERUI YOSHIHIRO
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- NAKAI HIROSHI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- YAGI SHIGENORI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- HATTORI NAOHIKO
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- FUJIWARA TAMIO
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- KAMIGAUCHI TOSHIYUKI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
書誌事項
- タイトル別名
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- I. Isolation, Structure Elucidation and Biological Activities
抄録
Two novel compounds, stachyflin and acetylstachyflin, have been isolated by solid-state fermentation of Stachybotrys sp. RF-7260. The structures of both metabolites, determined by detailed NMR analyses and X-ray crystallographic analysis, are novel with a pentacyclic moiety including cis-fused decalin. The absolute stereochemistry of stachyflins was determined by circular dichroism analysis. Stachyflin showed antiviral activity against influenza A virus (H1N1) in vitro with an IC50 value of 0.003μM. Acetylstachyflin was about 77-fold less active than stachyflin.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 55 (2), 155-164, 2002
公益財団法人 日本感染症医薬品協会
