Distribution of tissue bile acids in the human alimentary tract and colon polyps.

DOI Web Site PubMed
  • NAKASHIMA Toshiaki
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SETO Yoshifumi
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • NAKAJIMA Toshikazu
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SHIMA Toshihide
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SAKAMOTO Yoshikuni
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SANO Atsushi
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • TAKINO Tatsuro
    The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

Abstract

To determine the characteristic distribution of tissue-bound bile acids in the human alimentary tract and colon polyps, we measured the concentration of bile acids in the mucosal tissues of the alimentary tract obtained at autopsy and polyps obtained by endoscopic polypectomy, using enzymatic fluorimetry and gas-liquid chromatography. The concentration of tissue-bound bile acid, especially chenodeoxycholic acid, was significantly higher in the ileum or ascending colon than in the other portions of the alimentary tract. The bile acid level of polyps was also higher in the ascending colon than in the other portions of the colon. These results suggest that the high concentration of tissue-bound bile acids is obtained at the site of absorption of bile acids in the alimentary tract.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top