Protection of the tryptophan indole ring in peptide synthesis. Use of a new derivative, Nin-2,2,2-trichloroethoxycarbonyltryptophan.
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The 2,2,2-trichloroethoxycarbonyl (Troc) group attached at the <I>N</I><SUP>in</SUP> function of tryptophan by acylation with Troc-Cl in the presence of a catalytic amount of tetra-<I>n</I>-butylammonium hydrogensulfate can be quantitatively removed either by cadmium dust in acetic acid or under basic conditions, e.g., hydrazine hydrate and NaOH, but is resistant to strong acidic conditions.
- Chemistry Letters
Chemistry Letters 12(5), 739-742, 1983
The Chemical Society of Japan