Transformation of Polyoxins D, E, and F with Sodium Bisulfite
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Polyoxins D, E, and F which possess 5-carboxyuracil as the nucleobase were reacted selectively with sodium bisulfite at pH 4.0 resulting in facile decarboxylation to afford corresponding 5, 6-dihydrouracil-6-sulfonates and uracil type polyoxins (polyoxins L, M, and K) in good yield. The former compounds were also converted to the latter almost quantitatively with mild alkali treatment. Biological activities of the transformed compounds were described.
- Agricultural and Biological Chemistry
Agricultural and Biological Chemistry 36(7), 1229-1236, 1972
Japan Society for Bioscience, Biotechnology, and Agrochemistry