Reaction of 5-Carboxypyrimidine Derivatives with Sodium Bisulfite

• ISONO Kiyoshi

  The Institute of Physical and Chemical Research

• SUZUKI Saburo

  The Institute of Physical and Chemical Research

• TANAKA Michio

  Kaken Chemical Co., Ltd.

• NANBATA Takeo

  Kaken Chemical Co., Ltd.

• SHIBUYA Kunitoyo

  Kaken Chemical Co., Ltd.

書誌事項

タイトル別名

• A Facile Decarboxylation Method

抄録

5-Carboxyuracil derivatives were shown to react with aqueous sodium bisulfite in mild condition resulting in facile decarboxylation to give corresponding 5-decarboxy-5, 6-dihydrouracil-6-sulfonates and uracils in good yield. The former compounds were quantitatively transformed to the latter in alkaline condition. Mechanistic feature of this reaction was discussed, which implied the initial nucleophilic addition of bisulfite across the 5, 6-double bond. 5-Carboxycytosine was also shown to react similarly, however, accompanied by hydrolytic deamination.

収録刊行物

• Agricultural and Biological Chemistry

  Agricultural and Biological Chemistry 36 (9), 1571-1579, 1972

  公益社団法人 日本農芸化学会

キーワード

• General Agricultural and Biological Sciences
• General Biochemistry, Genetics and Molecular Biology

詳細情報

• CRID: 1390282681447069952
• NII論文ID: 130003524023
• DOI: 10.1271/bbb1961.36.1571
• COI: 1:CAS:528:DyaE3sXhs1elsQ%3D%3D
• ISSN: 18811280
• ISSN: 00021369
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可