Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss.
-
- Kim Hyoun-Ju
- Tohoku University Gene Research Center
-
- Kim Dong-Ho
- Tohoku University Gene Research Center
-
- Magoori Kenta
- Tohoku University Gene Research Center
-
- Saeki Shigeru
- The Department of Food and Nutrition, Osaka City University
-
- Yamamoto Tokuo T.
- Tohoku University Gene Research Center
抄録
The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by "exon shuffling." Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.
収録刊行物
-
- The Journal of Biochemistry
-
The Journal of Biochemistry 124 (2), 451-456, 1998
The Japanese Biochemical Society
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1572261553034624640
-
- NII論文ID
- 130003533520
-
- ISSN
- 0021924X
-
- 本文言語コード
- en
-
- データソース種別
-
- CiNii Articles