Four Patients with Polyendocrinopathy with Associated Pituitary Hormone Deficiency.

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Author(s)

Abstract

Four cases of polyglandular endocrine disorders associated with pituitary hormone secretion failure are reported. Three of them had both insulin dependent diabetes mellitus (IDDM) and Hashimoto's disease. Each of these patients (cases 1-3) showed isolated deficiency of ACTH, TSH or gonadotropin, respectively. Another patient (case 4) had both Hashimoto's disease and isolated ACTH deficiency. Anti-pituitary antibody to AtT-20 cells was detected in case 1. Serum gamma-globulins from patients 1 and 4 attenuated corticotropin releasing hormone-induced ACTH release in monolayer cultured rat anterior pituitary cells. Gamma-globulins from patients 1 and 2 decreased baseline TSH release but stimulated baseline prolactin release in pituitary cell cultures. It is possible that pituitary hormone deficiency in these patients may be caused by autoimmune disorders.

Journal

  • Endocrine Journal

    Endocrine Journal 41(6), 613-621, 1994

    The Japan Endocrine Society

Codes

  • NII Article ID (NAID)
    130003549466
  • Text Lang
    ENG
  • ISSN
    0918-8959
  • Data Source
    J-STAGE 
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