Clinical Courses and Thyroid Conditions in Three Infants Born to a Mother with Thyroid Stimulating-Blocking Antibodies.
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- NOTSU KAZUMI
- Division of Endocrinology and Metabolism, Department of Medicine, Shimane Prefectural Central Hospital
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- ITO YASUO
- Division of Endocrinology and Metabolism, Department of Medicine, Shimane Prefectural Central Hospital
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- HASEGAWA AKIHIRO
- Department of Gynecology and Obstetrics, Shimane Prefectural Central Hospital
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- IWANARI OSAMU
- Department of Gynecology and Obstetrics, Shimane Prefectural Central Hospital
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- KATAMURA KENJI
- Department of Pediatrics, Shimane Prefectural Central Hospital
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- KIKUCHI KIYOSHI
- Department of Pediatrics, Shimane Prefectural Central Hospital
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- OHGUNI SATOSHI
- The First Division, Department of Medicine, Shimane Medical University
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- FURUYA HIROSHI
- The First Division, Department of Medicine, Shimane Medical University
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- SOHMIYA MOTOI
- The First Division, Department of Medicine, Shimane Medical University
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- KATO YUZURU
- The First Division, Department of Medicine, Shimane Medical University
抄録
The clinical courses including thyroid conditions of three infants born to a mother with primary hypothyroidism due to Hashimoto's thyroiditis were studied. The mother was positive for both TSH-binding inhibitor immunoglobulins (TBII) and thyroid stimulating-blocking antibodies (TSBAb) in her serum. The first infant died because of septic shock due to fistula formation between the large intestine and the bladder. Serum thyroid hormone levels during the first pregnancy were extremely low because of incomplete replacement therapy with levothyroxine. The second infant had almost normal thyroid function, so that the replacement therapy was not necessary. The third infant had transient and overt primary hypothyroidism. The replacement therapy was carried out for six months after birth. TSBAb activities in this mother were high in the third pregnancy. In general, these activities gradually increases with the clinical course in TSBAb-positive Hashimoto's patients. From these findings, it was suspected that the thyroid conditions in the second and the third infants reflected the natural course of TSBAb activities in this mother.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 44 (2), 233-237, 1997
一般社団法人 日本内分泌学会