帝王切開術中に用いる子宮収縮薬の体循環への影響および副作用について　　オキシトシンとプロスタグランジンＦ２αの比較

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  • Effects of Uterine Constrictors during Caesarean Section under Spinal Anesthesia. A Comparative Study of Oxytocin and Prostaglandin F2.ALPHA..
  • a Comparative Study of Oxytocin and Prostaglandin F<sub>2α</sub>
  • オキシトシンとプロスタグランジンF<sub>2α</sub>の比較

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We retrospectively compared the effects of intravenous oxytocin (OX) with those of prostaglandin F2a (PGF2a) during elective caesarean section in 68 otherwise healthy women who were operated on under spinal anesthesia. The OX group (n=34) received intravenous infusion of OX 5U over 20 to 30 minutes and the PGF2a group (n=34) received 500μg of intramyometrial PGF2a after clamping of the umbilical cord. Demographic data were comparable in the two groups. The increase in systolic blood pressure was greater in the PGF2a group than in OX group (p<0.05). Side effects were higher in PGF2a group than in the OX group, 24 cases (71%) versus 11 cases (32%) (p<0.05). Requirement of an additional dosage of uterine constrictor was higher in the PGF2a group than in OX group, 16 patients (47%) versus 2 patients (6%) (p<0.05). We conclude that OX is a better uterine constrictor than PGF2a.

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