乳癌術後ｔａｍｏｘｉｆｅｎ投与中に大きな子宮内膜ポリープと対側乳房Ｐａｇｅｔ病を併発した１例

DOI Web Site

書誌事項

タイトル別名
  • A case of large endometrial polyp and paget's disease of the right breast occurred in a patient under tamoxifen(TAM) regimen after operation for left breast cancer.

この論文をさがす

抄録

The authors describe a case of large endometrial polyp possibly due to tamoxifen (TAM) regimen associated with Paget's disease of the right breast in a postoperative woman with left breast cancer. A 71-year-old woman was admitted to the hospital because of nipple eczema. She had been administered TAM for two years after the previous operation for left breast cancer. As she was diagnosed as having Paget's disease of the contralateral breast by a biopsied specimen, a right mastectomy was performed. Furthermore, a large endometrial polyp 4.0cm in maximum diameter was detected and it was extirpated. Though TAM is widely used as an adjuvant hormone therapy for breast cancer, two years or more prolonged TAM treatment causes proliferative endometrial lesions due to its partial estrogenic action. On the other hand, significant reductions in the incidence rate of contralateral breast cancer have been observed. ER of Paget's cells revealed negative by an immunohistochemical study in this case. Gynecological examination is necessary for the patients administered TAM in spite of the cumulative dose and duration of the regimen.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ