大腸癌におけるcadherin, lamininの免疫組織発現からみた肝転移予測

• 小川 匡市

  東京慈恵会医科大学外科

• 池内 健二

  東京慈恵会医科大学外科

• 渡部 通章

  東京慈恵会医科大学外科

• 金子 靖

  東京慈恵会医科大学外科

• 衛藤 謙

  東京慈恵会医科大学外科

• 藤川 亨

  東京慈恵会医科大学外科

• 高尾 良彦

  東京慈恵会医科大学外科

• 穴澤 貞夫

  東京慈恵会医科大学外科

• 山崎 洋次

  東京慈恵会医科大学外科

書誌事項

タイトル別名

• EXPRESSION OF LAMININ AND CADHERIN ASSOCIATED WITH LIVER METASTASIS IN HUMAN COLORECTAL CANCER -AN APPROACH FROM IMMUNOHISTOCHEMISTRY-

抄録

The significance of laminin and cadherin expression in human colorectal cancer was investigated by immunohistochemical assay, and its correlation with liver metastasis was analyzed. In the synchronous metastasis group, 17 of 34 cases (50%) showed positive staining of laminin, 14 (41%) of cadherin, and 5 (14%) a decreased rate of cadherin. In the metachronous metastasis group, 17 of 30 (57%) showed positive staining of laminin, 12 (40%) of cadherin, and 6 (20%) a decreased rate of cadherin. In a control group (free of disease for 5 years), in spite of no significant differences in clinicopathological factors compared with the other two groups, only 2 of 37 cases (5%) showed positive staining of laminin, 8 (22%) in cadherin, and 2 (5%) a decreased rate of cadherin. Thus, the metastatic groups were significantly higher than the control group in expression of laminin, but no significant difference in expression of cadherin was observed. These findings suggest that laminin is a useful parameter for predicting liver metastasis.

収録刊行物

• 日本臨床外科学会雑誌

  日本臨床外科学会雑誌 61 (5), 1135-1139, 2000

  日本臨床外科学会

キーワード

• colorectal cancer
• liver metastasis
• immunohistochemistry
• cadherin
• laminin

詳細情報

• CRID: 1390282679827168384
• NII論文ID: 130003601935
• NII論文ID: 10009379420
• NII書誌ID: AA11189709
• DOI: 10.3919/jjsa.61.1135
• ISSN: 18825133
• ISSN: 13452843
• Web Site: http://www.jstage.jst.go.jp/article/ringe1998/61/5/61_5_1135/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000249495
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可