再発乳癌に対するｐａｃｌｉｔａｘｅｌ　ｗｅｅｋｌｙ投与の臨床的検討

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  • Clinical study of weekly paclitaxel administration for metastatic breast cancer.

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We studied 14 women aged 36-42 years treated by weekly administration of paclitaxel for metastatic breast cancer. Paclitaxel was administered in 1-hour intravenous infusion at a dose of 60-80 mg/m2 once a week. Administration was continued for 3 weeks with a 1-week rest in at least 3 cycles. Administration was first-line in 2, second-line in 5, and third-line in 7. Overall response was 71.4% among 10 partial responders and no complete responders.<br> At reccurrence sites, response was 75% in the liver, 100% in the lung, 12% in bone, and 87% at local sites. Pain was ameliorated in 6 of 7 patients and local recurrence tumors decreased in 4 cases. Tumor markers decreased in 6 of 10. Side effects involved grade 3/4 leukopenia in 36%, peripheral neuropathy in 5, and appetite loss in 3 grade 1 cases. Weekly administration of paclitaxel thus appears well tolerated and effective against metastatic breast cancer.

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