Drug-dependent cellular cytotoxicity mediated by polymorphonuclear leukocytes.
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- IKENAMI Michihiro
- Faculty of Pharmaceutical Sciences, Teikyo University
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- MIZUNO Den'ichi
- Faculty of Pharmaceutical Sciences, Teikyo University
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- YAMAZAKI Masatoshi
- Faculty of Pharmaceutical Sciences, Teikyo University
抄録
Several anticancer drugs were tested for induction of cytolysis mediated by poly-morphonuclear leukocytes (PMNs). Among them, actinomycin D and vincristine sulfate induced tumor lysis mediated by PMNs (drug-dependent cellular cytotoxicity). The cell-free supernatant of PMNs incubated with actinomycin D in vitro could lyse various murine tumor cells, although normal spleen cells and sheep red blood cells were not lysed. The cytolytic activity of the supernatant was resistant to treatment with superoxide dismutase, catalase, trypsin inhibitor or arginine. However, the cytolytic activity was labile to heat treatment at 56°(30min) or trypsin treatment, suggesting a protein nature. These results suggest that PMNs can lyse tumor cells in the presence of certain anticancer drugs and that a factor(s) from PMNs may participate in the killing of tumor cells.
収録刊行物
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- Japanese Journal of Cancer Research GANN
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Japanese Journal of Cancer Research GANN 76 (7), 637-643, 1985
The Japanese Cancer Association
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詳細情報
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- CRID
- 1573387452988442112
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- NII論文ID
- 130003608686
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- ISSN
- 09105050
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles