The tumor-initiating and -promoting effects of ionizing radiations in mouse skin.

• OOTSUYAMA Akira

  Radiobiology Division, National Cancer Center Research Institute

• TANOOKA Hiroshi

  Radiobiology Division, National Cancer Center Research Institute

抄録

The tumor-initiating and -promoting effects of ionizing radiation were tested, using mouse skin as the target organ and ⁹⁰Sr-⁹⁰Y beta-rays as the source of radiation. Neither single 2400 rad beta-irradiation followed by repetitive treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) nor single pretreatment with 7, 12-dimethylbenz[a]anthracene (DMBA) followed by repetitive 470 rad beta irradiation produced tumors above the level of significance within a period of 210 days, while a positive control, DMBA+TPA, yielded a high incidence of papilloma in a shorter period. DMBA exerted an action antagonistic to beta-rays in the induction of malignant tumors. It is concluded that the tumor-enhancing activity of repetitive radiation is qualitatively different from the promoting activity of TPA.

収録刊行物

• Japanese Journal of Cancer Research GANN

  Japanese Journal of Cancer Research GANN 78 (11), 1203-1206, 1987

  The Japanese Cancer Association

キーワード

• Ionizing radiation
• Initiation
• Promotion
• Mouse skin

詳細情報

• CRID: 1572543028059058688
• NII論文ID: 130003608891
• ISSN: 09105050
• Web Site: https://jlc.jst.go.jp/DN/JALC/00172386193?from=CiNii
• 本文言語コード: en
• データソース種別:
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