末梢神経再生における抗癌剤（ｃｉｓｐｌａｔｉｎ）の影響　第１報

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  • An Experimental Study of Effects of Cisplatin on Recovery of the Peripheral Nerve after Neurorrhaphy in Rats.

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We analysed the effect of cisplatin, which is the most common anti-neoplastic agent for the treatment of malignant bone and soft tissue tumors, on regeneration of the peripheral nerve.<br>Left sciatic nerve of Wister rat was elected for Site of neurorrhaphy. Three groups of rats were prepared as follows, Group 1: Cisplatin of 6mg/kg was weekly administrated throgh the tail vein after neurorrhaphy. Group 2: The dosage of cisplatin was 1.5mg/kg, it was administrated in the same manner. Group 3: Saline were injected in the same manner as a control. Each group consists of 12 rats, and they were functinally assessed by sciatic functional index 6 weeks after neurorrhaphy. After sacrifice, each specimen was histrogically evaluated.<br>The results showed no significant differences among three groups so far, and any adverse effect of cisplatin on nerve regeneration was proved.

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