書誌事項
- タイトル別名
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- Gene-based genome-wide association study on identification of susceptible genes of cerebral infarction
抄録
Recent research suggests that many genetic variants and environmental exposures might affect the occurrence and progression of common diseases including stroke. However, genetic risk factors for cerebral infarction, the most common type of stroke in developed countries, are almost unknown. We conducted a genome-wide association study using 1, 126 Japanese subjects with cerebral infarction and age-and sexmatched healthy controls selected from the participants of health examination survey of the Hisayama study in 2002 and 2003. We initially genotyped 188 cases for 52, 608 gene-based single nucleotide polymorphisms (SNPS) and compared their genotype distributions with those of 188 corresponding controls. We found 1, 098 SNPS with significant associations (p<0.01) in the initial screening and further genotyped these SNPS in the remaining cases and controls. As a result, 10 SNPs loci showed strong associations (p<0.0001) with cerebral infarction. When the subjects were examined by cerebral infarction subtypes, we found that another 2 SNPs loci were significantly associated with lacunar infarction. These loci might include susceptible genes for cerebral infarction. Further studies examining function of these genes are needed to clarify genetic risk factors for cerebral infarction in Japanese.
収録刊行物
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- 脳卒中
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脳卒中 27 (4), 602-606, 2005
一般社団法人 日本脳卒中学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204639552512
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- NII論文ID
- 130003631646
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- ISSN
- 18831923
- 09120726
- http://id.crossref.org/issn/09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可