直腸癌術後再発に対する温熱療法の治療成績

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  • Clinical Results of Hyperthermia for Postoperative Recurrences of Rectal Cancer.

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In the period from November 1984 until May 1993 hyperthermia was applied to seven patients with local recurrences of rectal cancer. For the heating we used a BSD made BSD-1000 for five patients and an Omron made HEH-500C for two patients. Hyperthermia was performed on the average 8.7 times (range : 3-18) for each patient for 60 minutes each. All patients underwent combined radiotherapy and received a mean radiation dose of 45 Gy (range : 9-60 Gy). Five patients underwent heating within 1 hour after irradiation and two patients simultaneously with the irradiation. Five patients underwent combined chemotherapy and two patients immunotherapy. Before the treatment all patients had painful lesions, but pain decreased posttherapeutically in six patients. Performance status improved in two patients. High carcinoembryonic antigen levels prior to the therapy in five patients decreased in all cases after treatment. Posttherapeutical computed tomograms revealed only minor response or no changes. After the treatment four patients died of exacerbations of recurrent tumors and two patients of distant metastases. The 50 % survival time after initiation of the treatment was 24 months. Hyperthermia combined with radiotherapy, chemotherapy and or immunotherapy was useful for the alleviation of pain in patients who developed local recurrence after surgery and could be expected to improve survival after recurrences.

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