レニン直接ラジオイムノアッセイ法による高齢者レニン‐アンジオテンシン系に関する研究

DOI Web Site PubMed 被引用文献1件

書誌事項

タイトル別名
  • Evaluation of the relationship between aging and the renin-angiotensin system using direct radioimmunoassay with monoclonal antibodies.
  • レニン チョクセツ ラジオイムノアッセイホウ ニ ヨル コウレイシャ レニン

この論文をさがす

抄録

To investigate the effect of aging on the renin-angiotensin system, plasma renin activity (PRA) and total renin activity (TRA) were measured in 30 normal subjects consisting of 16 under 60 years of age (10 males, 6 females, average age 41±2) and 14 aged 60 or more (3 males, 11 females, average age 77±3). Simultaneously, plasma active renin concentration (PARC) and plasma total renin concentration (PRTC) and plasma total renin concentration (PTRC) were also measured using newly developed direct radioimmunoassay using monoclonal anti-renin antibody. Inactive renin activity (IRA) and plasma prorenin concentration (PPRC) were calculated as the difference of TRA and PRA or PTRC and PARC, respectively. PRA and the PRA/TRA ratio were decreased significantly with aging (PRA; from 2.2±0.5 to 0.7±0.1ng/ml·h: mean±SE, p<0.01, PRA/TRA; from 8.1±1.3 to 6.7±1.0. p<0.01), but TRA and IRA were unchanged. On the other hand, both PARC and PARC/PTRC decreased significantly with aging (PARC; from 35±5 to 17±2pg/ml, p<0.01, PARC/PTRC; 288±61 to 234±52, p<0.05), but PTRC and PPRC did not change significantly. A significant positive correlation was found between PRA and PARC (Y=10.9C+10.0, r=0.933, p<0.001). PTRC correlated with TRA (Y=38.8X-64.4, r=0.905, p<0.001). These results indicate that the conversion of proprenin to active renin may be impaired by aging in normotensive subjecs.

収録刊行物

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ