Role of Vitamin E in Immune System
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- Moriguchi Satoru
- Department of Nutrition, Faculty of Human Life Science, Yamaguchi Prefectural University
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- Kaneyasu Mayumi
- Department of Nutrition, Faculty of Human Life Science, Yamaguchi Prefectural University
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抄録
Vitamin E is a potent antioxidant and has an ability to modulate host immune functions. This manuscript consists of six parts:(1) vitamin E deficiency and immunity, (2) vitamin E supplementation and immunity, (3) vitamin E and the decreased cellular immunity with aging, (4) vitamin E and T-cell differentiation in the thymus, (5) vitamin E and acquired immune deficiency syndrome (AIDS), and (6) vitamin E and the abnormal increase of host immune functions such as allergy and autoimmune diseases. In vitamin E deficiency most of the immune parameters show a downward trend, which is associated with increased infectious diseases and the incidence of tumors. In contrast, vitamin E supplementation has various beneficial effects on the host immune system. The decreased cellular immunity with aging or during the development of AIDS is markedly improved by the intake of a high vitamin E diet. In addition, vitamin E plays an important role in the differentiation of immature T cells in thymus. Vitamin E deficiency induces the decreased differentiation of immature T cells, which results in the early decrease of cellular immunity with aging in spontaneously hypertensive rats. Conversely, vitamin E supplementation induces a higher differentiation of immature T cells via increased positive selection by thymic epithelial cells, which results in the improvement of decreased cellular immunity in the aged. Furthermore, some reports have shown that vitamin E has an ability to modulate the development of allergy or autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Taken together, all of the evidence suggest that vitamin E is a potent vitamin for modulating not only decreased immunity shown in the aged but also abnormally increased host immune system in patients with allergy or autoimmune diseases.
収録刊行物
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 34 (3), 97-109, 2004
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1390001204672839168
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- NII論文ID
- 130003670602
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可