書誌事項
- タイトル別名
-
- Effect of Prostacyclin and its Derivatives on Airways, the Pulmonary Vascular System and on Chemical Mediator Release
この論文をさがす
抄録
Prostacyclin (Prostaglandin I2) is well known as a potent vasodilator and has an antiaggregatory effect. In the present investigation we studied the effects of prostacyclin, carbacyclin and R-59274 on rabbit pulmonary artery, descending aorta and guinea pig tracheal strips, and investigated the effects of these substances on anaphylactic release of chemical mediators from passively sensitized guinea pig lung tissues.<br>1) Carbacyclin and R-59274 showed marked relaxation responses in rabbit pulmonary artery and descending aorta strips.<br>2) Prostacyclin, carbacyclin and R-59274 showed relaxation responses in guinea pig tracheal strips with continuous infusion of neostigmine bromide. Relaxation responses of prostacyclin, carbacyclin and R-59274 were almost 1/100 in comparison to those of PGE2, while 6-keto PGF1α, a stable metabolite of prostacyclin, showed relaxation responses almost 3 times stronger than those of the three above drugs.<br>3) Prostacyclin, carbacyclin and R-59274 attenuated the action of various bronchoconstrictors dose-dependently in guinea pig tracheal tissues.<br>4) Prostacyclin, carbacyclin and R-59274 inhibited the release of chemical mediators such as histamine and SRSA from passively sensitized guinea pig lung tissues.<br>The above results suggest that endogenous prostacyclin has a bronchodilating effect and an inhibiting effect on chemical mediator release from lung mast cells besides those well known effects such as vasodilation, hypotension and antiaggregation.<br>The stable derivatives of prostacyclin, carbacyclin and R-59274, might become useful drugs for various pathological conditions.
収録刊行物
-
- 日本胸部疾患学会雑誌
-
日本胸部疾患学会雑誌 21 (4), 334-339, 1983
社団法人 日本呼吸器学会
