喫煙と肺の代謝 ヒト血中補体Ｃ３ａ値，Ｃ５ａ値におよぼす喫煙の影響について Cigarette smoking and lung metabolism. Effect of cigarette smoking on plasma levels of complement C3a and C5a in healthy volunteers.
健康成人男子26名に紙巻タバコ5本を20～30分間という短時間内に喫煙させ, 血中補体C3a値およびC5a値を radioimmunoassay 法を用い測定した. 血中C3a値およびC5a値はいずれも喫煙終了直後に有意な上昇を示し, 喫煙終了20分後にも増加する傾向を示した.
Twenty-six adult healthy volunteer smokers were requested to refrain from smoking on the day of the experiment, then to smoke 5 cigarettes within 20 to 30 minutes. Before, immediately and 20 minutes after the cigarette smoking, peripheral venous blood was collected for the assay of complement C3a and C5a.<br>The plasma level of complement C3a and C5a showed significant increases, immediately and 20 minutes after the cigarette smoking.<br>The above results may suggest that cigarette smoke exposure increased the plasma levels of complement C3a and C5a in healthy volunteers.
日本胸部疾患学会雑誌 26(10), 1029-1032, 1988
The Japanese Respiratory Society