若年健康女性におけるbasal bronchomotor toneと深吸気のmaximum expiratory flow (Vmax)増加効果の関係  [in Japanese] Effect of deep inspiration of maximum expiratory flow (Vmax) depends on basal bronchomotor tone in young healthy females.  [in Japanese]

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Abstract

若年健康女性にみられる深吸気の Vmax 増加効果と basal bronchomotor tone の関係にっいて, partial and maximum expiratory flow-volume curve を用いて検討した. 深吸気の Vmax 増加効果は, ipratropium bromide によるPEF<sub>25</sub>の増加率 (r=-0.81, p<0.0002) および salbutamol によるPEF<sub>25</sub>の増加率 (r=-0.62, p<0.01) と有意の相関を示した. 深吸気の Vmax 増加効果の日差変動は, PEF<sub>25</sub>の日差変動と有意 (r=0.68,p<0.005) に相関したが, MEF<sub>25</sub>の日差変動とは相関しなかった. 以上より, 若年健康女性における深吸気の Vmax 増加効果は, 迷走神経緊張による basal bronchomotor tone が亢進しているためにみられる現象と考えた.

The relationship between the effect of deep inspiration on V<sub>max</sub> and basal bronchomotor tone was studied by partial and maximum expiratory flow-volume curve in 16 young healthy females (20-21 years old).<br>Effect of deep inspiration on V<sub>max</sub> (DI index; (PEF<sub>25</sub>-MEF<sub>25</sub>)/PEF<sub>25</sub>) significantly related to percent increase in PEF<sub>25</sub> not only by inhalation of ipratropium bromide (r=-0.81, p<0.0002) but also by inhalation of salbutamol (r=-0.62, p<0.01). Furthermore, day to day variation of DI index significantly related to day to day variation of PEF<sub>25</sub> (r=0.68, p<0.005) but not to that of MEF<sub>25</sub>.<br>These findings suggest that the bronchodilating effect of deep inspiration in young healthy females may depend on intensity of basal bronchomotor tone caused by tonic vagal nerve activity.

Journal

  • The Japanese journal of thoracic diseases

    The Japanese journal of thoracic diseases 28(1), 105-112, 1990

    The Japanese Respiratory Society

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