ラット肝ミトコンドリヤの脂肪酸酸化におよぼすリボフラビン欠乏の影響

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タイトル別名
  • Effect of Riboflavin Deficiency on Fatty Acid Oxidation of Rat Liver Mitochondria
  • ラット ギモ ミトコンドリヤ ノ シボウサン サンカ ニ オヨボス リボフラビン ケツボウ ノ エイキョウ

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The effect of ribofiavin on the oxygen consumption of rat liver mitochondria with derivatives of palmitic acid was studied. It was found that under riboflavin deficiency decrease of oxidation of palmityl-CoA in the presence of L-carnitine was greater than that of palmityl-L-carnitine.<BR>When weanling rats were fed with riboflavin supplemented diet for 18 days and then with the deficient diet for following 31 days, the oxidative activity of palmityl-CoA with mitochondria in the presence of L-carnitine was reduced to the same level of that in rat fed with the deficient diet, whereas the reduction of that to palmityl-L-carnitine was less than that to palmityl-CoA in the presence of L-carnitine.<BR>The respiratory control ratio of the mitochondria was decreased by feeding the deficient diet for 4 weeks with both derivatives of palmitic acid. However, the rate of oxidative phosphorylation was not affected by the deficiency, using palmityl-L-carnitine as a substrate.

収録刊行物

  • 栄養と食糧

    栄養と食糧 25 (9), 681-685, 1972

    公益社団法人 日本栄養・食糧学会

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