書誌事項
- タイトル別名
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- Intra-articular injection therapy of MR-20S (ulinastatin) for osteoarthritis of the knee joint: Effect on joint markers.
- <I>Effect on joint markers</I>
- ―関節マーカーへの影響―
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抄録
Intra-articular injections of MR-20S (ulinastatin, urinary trypsin inhibitor) were performed for 16 knee joints of 16 patients (6 males, 10 females, average age 65.1±8.2) with osteoarthritis (OA) .<BR>Levels of 7 joint markers in the synovial fluids were measured before and after injection therapy. Levels of chondroitin 4-sulfate (C-4S), 6-sulfate (C-6S) and hyaluronic acid (HA) were measured using HPLC. Levels of type II procollagen C-peptide (pCOL II-C), MMP-3, TIMP-1 and PMN elastase were measured by ETA. Levels of pCOL II-C increased significantly after injections (p<0.01) . In the patients with C-4S levels of≥15 nmol/ml or C-6S levels of≥40 nmol/ml before injection, these chondroitin isomers decreased significantly (p<0.01) . No significant changes of HA, MMP-3, TIMP-1 and PMN elastase levels were observed after injection.<BR>The present data suggested that intra-articular injection of MR-20S might affect the metabolism of cartilage and synovium in OA.
収録刊行物
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- 炎症
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炎症 16 (5), 357-361, 1996
日本炎症・再生医学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204785975552
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- NII論文ID
- 130003709489
- 10009357653
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- NII書誌ID
- AN00357213
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- ISSN
- 18844006
- 03894290
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可