子宮頚部明細胞腺癌の1例  [in Japanese] Clear cell adenocarcinoma of the cervix unrelated to diethylstilbestrol exposure.  [in Japanese]

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Author(s)

    • 平井 康夫 HIRAI Yasuo
    • 癌研究会附属病院婦人科|癌研究会附属病院細胞診断部 Department of Gynecology, Cancer Institute Hospital|Department of Cytology, Cancer Institute Hospital
    • 芳賀 厚子 HAGA Atsuko
    • 癌研究会附属病院婦人科|埼玉協同病院産婦人科 Department of Gynecology, Cancer Institute Hospital|Department of Obstetrics and Gynecology, Saitama Kyoudou Hospital
    • 山内 一弘 YAMAUCHII Kazuhiro
    • 癌研究会附属病院婦人科|癌研究会附属病院細胞診断部 Department of Gynecology, Cancer Institute Hospital|Department of Cytology, Cancer Institute Hospital
    • 荷見 勝彦 HASUMI Katsuhiko
    • 癌研究会附属病院婦人科|癌研究会附属病院細胞診断部 Department of Gynecology, Cancer Institute Hospital|Department of Cytology, Cancer Institute Hospital

Abstract

本邦ではまれな子宮頸部明細胞腺癌の1例を経験したので報告する.症例は47歳, 女性.子宮癌検診にて子宮頸部上皮内癌を指摘され当科を紹介された.外来受診時および入院時に行われた子宮頸部細胞診により, 子宮頸部明細胞腺癌を推定診断し得た.細胞所見では, 明細胞型の腫瘍細胞と, 大型裸核腫瘍細胞を認めた. 明細胞型の腫瘍細胞は, レース状の淡い豊富な細胞質が目立っが, その他の所見は内頸部型腺癌の細胞学的所見と同様で, この所見単独では, 明細胞腺癌の推定診断は困難であった.しかし, 散在性に大型で著明に腫大した核小体をもつ大型裸核腫瘍細胞が多数出現していることから本疾患の推定が可能であった.子宮頸部明細胞腺癌は, まれな疾患であるが本疾患の進行例の予後は不良であることから, 細胞診スクリーニングによる早期の診断推定は重要である.

We report a case of clear cell adenocarcinoma of the cervix (CCAC) unrelated to diethylstilbestrol exposure. The patient was a 47-year old female.<BR>The patient had been diagnosed as having carcinoma <I>in situ</I> at another hospital, and was relerred to our hospital.<BR>On cytologic examinations, two types of tumor cells were recognizable, i.e., “clear cell type” and “large naked nuclei type”. “Clear cell type” tumor cells showed light richlylaced cytoplasma. On the other hand, “large naked nuclei type” cells were scattered around clusters of “clear cell type” cells. These cytologic findings of two distinct cell types allowed us to diagnose this case as CCAC.<BR>CCAC is a very rare disease. However early diagnosis of this disease based on by cytologic screening is important because the prognosis of advanced CCAC is reportedly unfavorable.

Journal

  • The Journal of the Japanese Society of Clinical Cytology

    The Journal of the Japanese Society of Clinical Cytology 35(6), 600-603, 1996

    The Japanese Society of Clinical Cytology

Codes

  • NII Article ID (NAID)
    130003758642
  • Text Lang
    JPN
  • ISSN
    0387-1193
  • Data Source
    J-STAGE 
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