Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).

• 塚元 久雄

• 寺田 精介

抄録

The ester-type glucuronide of p-hydroxybenzoic acid was isolated as two derivatives from the urine of rabbits receiving p-hydroxybenzoic acid and their structures were established as methyl (p-methoxybenzoyl 2, 3, 4-tri-O-acetyl-β-D-glucopyranosid) uronate and methyl (p-acetoxybenzoyl 2, 3, 4-tri-O-acetyl-β-D-glucopyranosid) uronate. When feeding p-hydroxybenzoic acid to rabbits, similarly as in using the methyl ester, the unchanged acid, p-hydroxyhippuric acid, the ether-type glucuronide, the estertype glucuronide, and p-carboxyphenyl sulfate were excreted as five metabolites in the urine.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 10 (2), 91-95, 1962

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204173996672
• NII論文ID: 110003618809
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.10.91
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/10/2/10_2_91/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1963047299
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可