Studies on Steroidal Compounds. VII. Synthesis of 1α-Methyl Steroids.

• 森 弘

抄録

The Grignard reaction of 5α-cholest-1-en-3-one (IIIa) in the presence of cuprous chloride gave 1α-methyl-5α-cholestan-3-one (IVa). (IVa) was brominated and dehydrobrominated to give 1α-methylcholest-4-en-3-one (VIa). (VIa) was hydrogenated over palladium-charcoal to give 1α-methyl-5β-cholestan-3-one (VII). Discussions were made on configuration of C-1 methyl group. Similarly, 17β-hydroxy-5α-androst-1-en-3-one (IIIb) was transformed into (IVb) and (VIb).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 10 (5), 386-390, 1962

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679145763328
• NII論文ID: 110003618868
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.10.386
• COI: 1:STN:280:CC2D2sjkvFY%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 14476005
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/10/5/10_5_386/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1963039630
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可