Stereochemistry of Steroid containing Aromatic A-Ring. I. Reaction of 9 (11)-Dehydroestrone.

• 津田 恭介

• 野副 重男

• 岡田 泰

抄録

Bromination of 3-methoxy-9 (11)-dehydroestrone (II) gave equilenin methylether (IV). Hydroxybromination of 3-acetoxy-9 (11)-dehydrostrone (III) with N-bromosuccinimide in the presence of perchloric acid afforded a bromohydrin (VI), whose structure was assigned 3, 9α-dihydroxy-11β-bromoestra-1, 3, 5 (10)-trien-17-one 3-acetate, on the basis of the resistance of hydroxyl group to acetylation and oxidation, and by leading to 9α, 11α-epoxide (VII) and triol (IX).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 11 (8), 1022-1027, 1963

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204173624064
• NII論文ID: 110003619228
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.11.1022
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5888544
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/11/8/11_8_1022/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967053843
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可