Studies on Digitalis Glycosides. XIX. Microbiological Transformation of Digitoxigenin Derivatives by Absidia orchidis

• 奥村 保

• 野崎 義雄

• 佐藤 大助

抄録

Through the microbiological transformation of 3β, 14, 21-trihydroxy-14β-pregnan-20-one (III) and 4, 5-dehydrodigitoxigenone (IV) by Absidia orchidis, several kinds of products were isolated, and the structure and configuration of three hydroxylated products, one from III and two from IV, were clarified ; 1β, 3β, 14, 21-tetrahydroxy-14β-pregnan-20-one (V), 7β, 12β-dihydroxy-4, 5-dehydrodigitoxigenone (VIII), and 7β-hydroxy-4, 5-dehydrodigitoxigenone (IX). Based on these experimental results, the relationships between the structure of substrate and the positions to be hydroxylated in the microbiological transformation of cardiac aglycone derivatives by A.orchidis were discussed.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 12 (10), 1143-1151, 1964

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150543360
• NII論文ID: 110003619298
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.12.1143
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 14241627
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/12/10/12_10_1143/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967049639
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可