Synthesis of 2α-Halo-4-en-3-oxo-steroids

• 安田 喜久男

抄録

Some 2-ethoxalyl-4-en-3-one was treated with N-halo-succinimide in pyridine to give the corresponding 2α-halo-4-en-3-one in a good yield. Direct chlorination of testosterone acetate with sulfuryl chloride (1 mole) gave a small amount of 2α-chlorotestosterone acetate in dry beozene or dry ether, and with sulfuryl chloride (excess) gave mainly 2α, 4-dichlorotestosterone acetate in dry benzene and mainly 2α, 6β-dichlorotestosterone acetate in dry ether. These observations were confirmed by the syntheses of their related compounds through the unequivocal routes.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 12 (10), 1217-1224, 1964

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150685568
• NII論文ID: 110003619311
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.12.1217
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 14241640
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/12/10/12_10_1217/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967019782
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可